Microcircuit mechanisms involved in paired associative stimulation-induced depression of corticospinal excitability
نویسندگان
چکیده
منابع مشابه
Modulation of human corticospinal excitability by paired associative stimulation
BACKGROUND Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes an impairment in both the upper and lower motor neurons. The recent description of numerous non-motor signs points to an involvement of the neocortex networks that is more complex than was previously believed. Paired associative stimulation (PAS), a combination of transcranial magnetic stimulation (TMS) an...
متن کاملFailure of spinal paired associative stimulation to induce neuroplasticity in the human corticospinal tract.
CONTEXT/OBJECTIVE Paired associative stimulation (PAS) involves paired-stimulation pulses at both the head (via transcranial magnetic stimulation) and the periphery (via peripheral nerve stimulation). The purpose of PAS, when applied to the spinal cord, is to induce neuroplasticity and upregulate the corticospinal tract leading to effector muscles. While limited research has suggested that it i...
متن کاملNon-Invasive Brain Stimulation for Enhancement of Corticospinal Excitability and Motor Performance
During the past .. years, non-invasive .rain stimulation has .ecome an emerging .eld in clinical neuroscience due to its capability to transiently modulate corticospinal excitability, motor and cognitive functions. .hereas transcranial magnetic stimulation has .een used e.tensively since more than t.o decades ago as a potential .neuromodulator., transcranial current stimulation .tCS. has more r...
متن کاملAltered paired associative stimulation-induced plasticity in NMDAR encephalitis.
OBJECTIVE To determine whether neurophysiological mechanisms indicating cortical excitability, long-term potentiation (LTP)-like plasticity, GABAergic and glutamatergic function are altered in patients with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis and whether they can be helpful as markers of diagnostic assessment, disease progression, and potentially therapy response. METHODS ...
متن کاملChanges in Excitability of the Cortical Projections to the Human Tibialis Anterior Following Paired Associative Stimulation
Paired associative stimulation (PAS) based on Hebbs law of association can induce plastic changes in the intact human. The optimal interstimulus interval (ISI) between the peripheral nerve and transcranial magnetic stimulus is not known for muscles of the lower leg. The aims of the current study were to investigate the effect of PAS for a variety of ISIs and to explore the efficacy of PAS when ...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2013
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2013.253989